Genetic background of cholesterol gallstone disease
نویسندگان
چکیده
منابع مشابه
Genetic predisposition of cholesterol gallstone disease.
Gallstone disease (GSD) is the result of the interaction between genetic and environmental factors and it is a major disease cause of surgery with high costs to health systems. Worldwide prevalence varies according to the ethnic population suggesting that high prevalence of GSD in certain ethnic groups is due to the presence of genetic factors implicated in different metabolic pathways. However...
متن کاملGenetic factors in cholesterol gallstone disease
Most common diseases are strongly influenced by inheritance, but, to date, relatively few genes have been identified that are responsible for the familial clustering of these diseases. In the great majority of cases, no Mendelian inherited trait can be demonstrated. With the exception of cholesterol gallstones associated with low phospholipid level, induced by mutations in the gene of the multi...
متن کاملCholesterol gallstone disease.
With a prevalence of 10-15% in adults in Europe and the USA, gallstones are the most common digestive disease needing admission to hospital in the West. The interplay between interprandial and postprandial physiological responses to endogenous and dietary lipids underscores the importance of coordinated hepatobiliary and gastrointestinal functions to prevent crystallisation and precipitation of...
متن کاملHepatic cholesterol metabolism in cholesterol gallstone disease.
Hepatic cholesterol metabolism was examined in 27 Swedish patients with cholesterol gallstone disease and in 13 patients free of gallstones operated for roentgenographically suspect polyps in the gallbladder. All 40 patients underwent cholecystectomy, and a liver biopsy and gallbladder bile were obtained at surgery. The cholesterol saturation of gallbladder bile was significantly higher in pati...
متن کاملGenetic variation in the cholesterol transporter NPC1L1, ischaemic vascular disease, and gallstone disease.
AIMS Ezetimibe reduces plasma levels of low-density lipoprotein (LDL) cholesterol by inhibiting Niemann-Pick C1-Like protein 1 (NPC1L1), the transporter responsible for cholesterol uptake from the intestine into enterocytes and from the bile into hepatocytes. We tested the hypothesis that genetic variation in NPC1L1, mimicking the effect of ezetimibe, was associated with reduced risk of ischaem...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
سال: 2003
ISSN: 0925-4439
DOI: 10.1016/s0925-4439(02)00173-4